Joseph D. Fenstermacher, Ph.D.

Biography

• B.A., History, Augustana College, Sioux Falls, SD 1956
• M.S., Zoology, Michigan State University, East Lansing, MI 1959
• Ph.D., Physiology, University of Minnesota, Minneapolis, MN 1964

Awards, Honors and Publications

• 1981-83; 1988-1996: Editorial Board, J. Cereb. Blood Flow Metab.
• 1984-86: Ad hoc Member, Neurology B Study Section, NIH
• 1985-2000: Member or Chairman, Various NIH Site Visit Teams and ad hoc Study Sections
• 2000-Present Editorial Board, J. Neurosurgical Anesthesiology

• 1984 Jacob K. Javits Neuroscience Investigator Award (NIH)
• 1986 Co-winner, Heinz Karger Award
• 1989 K.A.C. Elliott Lecturer, Montreal Neurological Institute
• 1990 Outstanding Teaching, Medical School, SUNY, Stony Brook, NY

• Fagan SC, Nagaraja TN, Fenstermacher JD, Zheng J, Johnson M, Knight RA. Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a non-embolic stroke model. Neurol Res 2003;25: 377-382.
• Ewing JR, Knight RA, Nagaraja TN, Yee JS, Nagesh Y, Arniego PA, Fenstermacher JD. Patlak plots of GD-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Mag Reson Med 2003;50:283-292.
• Barton, KN, Tyson D, Stricker H, Lew YS, Heisey G, Koul S, de la Zerda A, Yin F-F, Yan H, Nagaraja TN, Randall KA, Kim JG, Fenstermacher JD, Jhiang S, Kim JH, Freytag SO, Brown SL. GENIS: Gene expression of sodium iodide symporter for non-invasive imaging of gene therapy vectors and quantification of gene expression in vivo. Molecular Therapy 2003;8:508-518.
• Brown, SL, Ewing JR, Nagaraja TN, Cao Y, Swerdlow PS, Fenstermacher JD, Kim JH. Sickle red blood cells accumulate in tumor. Magn Reson Med 2003;50:1209-1214.
• Barton KN, Xia X: Yan H, Stricker H, Heisey G, Yin F-F, Nagaraja TN, Zhu G, Kolozsvary A, Fenstermacher JD, Lu M, Kim JH, Freytag SO, Brown SL. A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors. Molecular Therapy 2004;9:625-631.
• Cao Y, Brown SL, Knight RA, Fenstermacher JD, Ewing JR. The effect of intravascular-to-extravascular water exchange on the determination of the blood-to-tissue transfer constant by MRI. Magn Reson Med 2005;53:282-293.
• Nagaraja TN, Patel P, Gorski M, Gorevic PD, Patlak CS, Fenstermacher JD. In Normal Rat Intraventricularly Administered Insulin-like Growth Factor-1 Is Rapidly Cleared from CSF with Limited Distribution into Brain. Cerebrospinal Fluid Res 2005;2:5-15.
• Knight RA, Nagaraja TN, Ewing JR, Nagesh V, Whitton PA, Bershad E, Fagan SC, Fenstermacher JD. Quantitation and Localization of Blood-to-Brain Influx by MRI and Quantitative Autoradiography in a Model of Transient Focal Ischemia Magn Reson Med 2005;54:4:813-21.
• Knight RA, Nagesh V, Nagaraja TN, Ewing JR, Whitton PA, Bershad E, Fagan SC, Fenstermacher JD. Acute BBB opening in experimentally induced focal cerebral ischemia is preferentially identified by quantitative magnetization transfer imaging. Magn Reson Med 2005;54:822-32.
• Ewing JR, Cao, Y, Knight RA, Fenstermacher JD. Arterial Spin labeling: validity testing and comparison studies. J Magn Reson Imag 2005;22:737-40.
• Ewing JR, Brown SL, Lu M, Panda S, Ding G, Knight RA, Cao Y, Jiang T, Nagaraja TN, Churchman J, Fenstermacher JD. Model selection in magnetic resonance imaging measurements of vascular permeability: Gadomer in a 9L model of rat cerebral tumor. J Cereb Blood Flow Metab 2006;26:310-320.
• Guo M, Roman RJ, Fenstermacher JD, Brown SL, Falck JR, Arbab AS, Edwards PA, Scicli AG. 9L Gliosarcoma cell proliferation and tumor growth in rats are suppressed by HET0016, a selective inhibitor of CYP4A. J Pharmacol Exp Ther 2006;317:97-108.
• Nagaraja TN, Croxen RL, Panda S, Knight RA, Keenan KA, Brown SL, Fenstermacher JD, Ewing JR. Application of arsenazo III in the preparation and characterization of an albumin-linked, gadolinium-based macromolecular magnetic resonance contrast agent. J Neurosci Meth 2006;157:238-45.
• Chen P, Scicli GM, Guo M, Fenstermacher JD, Dahl D, Edwards PA, Scicli GA. Role of angiotensin II in retinal leukostasis in the diabetic rat. Exp Eye Res 2006;83:1041-1051.
• Nagaraja TN, Knight RA, Croxen RL, Konda KP, Fenstermacher JD. Acute neurovascular unit protection by simvastatin in transient cerebral ischemia. Neurol Res 2006;157:238-245.
• Nagaraja TN, Keenan KA, Brown SL, Fenstermacher JD, Knight RA. Relative distribution of plasma flow markers and red cells across BBB openings in acute cerebral ischemia. Neurol Res 2007:29: 78-80.
• Nagaraja TN, Nagesh V, Ewing JR, Whitton PA, Fenstermacher JD, Knight RA. Step-down infusions of Gd-DTPA yield greater contrast-enhanced magnetic resonance images of acute stroke than bolus injections. Magn Reson Imag 2007; 25:311-318.
• Bagher-Ebadian, H, Nagaraja TN, Paudyal R, Whitton P, Panda S, Fenstermacher JD, Ewing JR. MRI estimation of contrast agent concentration in tissue using a neural network approach. Magn Reson Med 2007;58:290-297.
• Nagaraja TN, Keenan KA, Fenstermacher JD, Knight RA. Acute leakage of fluorescent plasma flow markers after transient focal cerebral ischemia suggests large openings of the blood-brain barrier. Microcirculation 2008,14:1-15.
• Ewing JR, Brown SL, Nagaraja TN, Paudyal R, Panda S, Bagher-Ebadian H, Knight RA, Ding G, Jiang Q, Lu M, Fenstermacher JD. An MRI measurement in the 9L rat cerebral tumor of change in vascular permeability after dexamethasone administration. Jour Magn Reson Imag 2008, 27:1430-1438
• Brown SL, Freytag SO, Barton KN, Flynn MJ, Peck DJ, Dragovic AF, Jin R, Yeni YN, Fyhrie DP, Les CM, Zhu G, Kolozsvary A, Pitchford WC, Nathanson SD, Fenstermacher JD, Kim JH. Reporter gene imaging using radioactive contrast from non-radioactive iodide sequestered by the sodium-iodide symporter. Contr. Media Molec. Imag. 2008 (in press).
• Kuroiwa T, Xi G, Hua Y, Nagaraja TN, Fenstermacher JD, Keep RF. Development of a rat model of photothrombotic ischemia and infarction within the caudoputamen. Stroke 2008, 40:248-253.
• Knight RA, Karki K, Ewing JR, Divine GW, Fenstermacher JD, Patlak CS, Nagaraja TN. Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[14C]DTPA. J Cereb Blood Flow Metab 2009 (in press).