Progressive multifocal leukoencephalopathy (PML) is a rare disorder that damages the material (myelin ) that covers and protects nerves in the white matter of the brain .
Alternative Names: PML
Causes, incidence, and risk factors:
The JC virus (JCV) causes PML. This virus is found in a lot of people, but usually does not cause symptoms. However, it triggers PML in people who have poor immune function (immunocompromised).
Treatment consists of antiviral drugs and other medications.
Support Groups:
Expectations (prognosis):
PML is a very serious condition. Talk to your doctor about care decisions.
Complications:
Calling your health care provider:
Prevention:
References:
Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 5th ed. London: Churchill Livingstone; 2000:1856-1861.
Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:2046.
Review Date: 2/13/2008 Reviewed By: Luc Jasmin, MD, PhD, Departments of Anatomy & Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
